Figure 5: A model for the mechanisms that translate interphase adhesion geometry to the mitotic spindle orientation. | Nature Communications

Figure 5: A model for the mechanisms that translate interphase adhesion geometry to the mitotic spindle orientation.

From: Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1

Figure 5

The translation starts at the onset of mitotic cell rounding, when the heterogeneity of interphase adhesion geometry leads to anisotropic activation of RhoA. The regions with high RhoA activation rapidly retract the cell edge, and generate the caveolin-1-associated CEMM at the proximal end of retraction fibres. Gαi1 is preferentially localized within the CEMM that guides the Gαi1 cortical crescent to the proximal end of the retraction fibres. Consequently, Gαi1/LGN/NuMA complexes direct the spindle axis towards the cortex enriched with retraction fibres.

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