Figure 6: Activation of CCKNTS and DBHNTS axon terminals in the PBN suppresses food intake. | Nature Communications

Figure 6: Activation of CCKNTS and DBHNTS axon terminals in the PBN suppresses food intake.

From: Genetically and functionally defined NTS to PBN brain circuits mediating anorexia

Figure 6

(a) Cartoon of a sagittal mouse brain depicting site of viral injections for either AAV1-DIO-ChR2:mCherry or AAV1-DIO-mCherry into the NTS and placement of fibre optic cannula for light administration in the PBN. (b,c) Photoactivation of CCKNTS (b) or DBHNTS (c) axon terminals in the PBN decreased food intake when measured 2 h after lights out compared to baseline, non-stimulated food intake, or food intake by stimulating mCherry-only controls. Data (n=6 per group) represent mean±s.e.m., *P<0.05 **P<0.01, ***P<0.001 (two-way repeated measures ANOVA and bonferroni post hoc comparison).

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