Figure 9: Conscious Trpc5−/− mice show deficiency in baroreflex regulation of heart rate.
From: TRPC5 channels participate in pressure-sensing in aortic baroreceptors
(a,b) Representative traces showing the heart rate reduction (HR) in response to elevation of mean arterial pressure (MAP) induced by i.p. phenylephrine injection (Phe; 20 μg g−1 body weight) in wild-type (WT; a) and Trpc5−/− (KO) mice (b). (c,d) Summarized data showing the baroreflex-mediated heart rate reduction in response to pressure increase. (c) The baroreflex curve over a range of MAP, statistical analysis was performed by two-way analysis of variance followed by Bonferroni post-test. (d) The overall baroreceptor sensitivity, which is the ratio of overall heart rate response divided by pressure change. Mean±s.e.m. n=7–8. *P<0.05 as compared with WT, statistical analysis was performed by Student’s t-test.
