Figure 2: V2 cellular eccentricity biases stochastic fate decision-making.
From: Memory of cell shape biases stochastic fate decision-making despite mitotic rounding
(a) Alteration of the direction of the asymmetric elongation of the V2 cell shape by femtosecond laser irradiation. The spiky ends of the old (yellow arrow) and new (orange arrow) axes are indicated. (b) Along values, axis changes and θfate for individual V2 cells on femtosecond laser irradiation are shown as 3D plot. The two-dimensional plots of axis change—Along and axis change—θfate are shown in c and d, respectively. Plotted are the cells with very little axis change (<45°) and θfate >90° (red open circle), significant axis change (>45°) and θfate >90° (blue open circle), little axis change (<45°) and θfate <90° (red closed circle) and significant axis change (>45°) and θfate <90° (blue closed circle). (e) Fates of the laser-irradiated V2 cells. (f) Summary. Fate decisions are made according to the newly acquired orientation of V2 cell shape asymmetry. Scale bar, 10 μm. NS, not significant. *P<0.05, **P<0.01 (χ2-test).
