Figure 1: SARI inhibits AOM/DSS-induced colonic carcinogenesis. | Nature Communications

Figure 1: SARI inhibits AOM/DSS-induced colonic carcinogenesis.

From: RETRACTED ARTICLE: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

Figure 1

(a) Schema of AOM/DSS treatments. (b) Representative macroscopic findings of colon tumours induced by AOM/DSS. (c,d) Number of macroscopic tumours (c) and tumour burden of AOM/DSS-treated mice (d) per colon. (SARIWT, n=9; SARI−/−, n=10; P<0.01; Student’s t-test). (e,f) H&E staining of SARIWT and SARI−/− colonic tissue after AOM/DSS treatment (e). Scale bar, 100 μm. Tumour area (%, tumour area/total area) was calculated (f, n=9, **P<0.01; Student’s t-test). (g) Western blot showing SARI expression in SARI and control SW480 and HCT116 cells. (h) Staining for SARI in SARI and SW480-control tumours. Scale bar, 50 μm. (i,j) Tumour volume (n=5; **P<0.01; Student’s t-test) and end-stage tumour weight (n=5; **P<0.01; Student’s t-test) after injection of 5 × 106 SARI and SW480-control cancer cells into nude mice. (k,l) Tumour volume (n=5; **P<0.01; Student’s t-test) and end-stage tumour weight (n=5; **P<0.01; Student’s t-test) after injection of 5 × 106 SARI and control HCT116 cancer cells into nude mice. (m,n) Tumour volume (n=5; **P<0.01; Student’s t test), and end-stage tumour weight (n=5; **P<0.01; Student’s t-test) after injection of 2 × 106 shSARI-1068 and shNC HCT15 cancer cells into nude mice. Ctrl, control.

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