Figure 4: Effect of PACAP eye drops on female Adcyap1−/− mice.
From: PACAP suppresses dry eye signs by stimulating tear secretion
(a) Tear secretion level in Adcyap1−/− mice after application of saline or 10−10 M PACAP38 eye drops (n=9 per group). *P<0.05 versus saline-treated group. (b,c) Corneal scoring before and after the repeated application of PACAP eye drops to Adcyap1−/− mice over a 3-week period. (b) Representative images of the corneal surface before and after eye drop application. Scale bar, 2 mm. (c) Eighteen female Adcyap1−/− mice were given saline or PACAP eye drops unilaterally. The classification of each side of the cornea was evaluated separately before, and 3 weeks after eye drop treatment commenced. *P<0.05.
