Table 1 Midpoint voltage of activation and steady-state inactivation with a standard Boltzmann distribution fit
 | Activation | Inactivation | ||
---|---|---|---|---|
 | V1/2 (mV) | K (mV) | V1/2 (mV) | K (mV) |
Nav1.5 stable | −33.4±0.3 | 7.8±0.2 | −90.4±0.6 | 7.1±0.5 |
Nav1.5 stable 2BP | −34.1±0.4 | 8.9±0.4* | −103±0.5* | 8.1±0.4* |
Nav1.5 stable PA | −29.9±0.4 | 7.7±0.4 | −83.4±0.4* | 6.3±0.4 |
Nav1.5 transient | −46.3±0.4 | 6.9±0.3 | −90.8±0.5 | 7.3±0.4 |
Nav1.5 transient 2BP | −50.8±0.6 | 7.8±0.5 | −108.4±0.7* | 9.7±0.6 |
Nav1.5-AAAA | −48.2±0.4 | 8.1±0.4 | −103.4±0.7†| 9.0±0.6 |
Nav1.5-AAAA 2BP | −50.4±0.5 | 7.7±0.4 | −106.0±0.5 | 8.4±0.5 |
Nav1.5 C981F | −50.2±0.5 | 8.1±0.4 | −100.2±0.5†| 6.9±0.4 |
Nav1.5 C981F 2BP | −52.6±0.4 | 7.3±0.4 | −100.7±0.7 | 8.3±0.6 |
Nav1.5 C981A | −47.8±0.7 | 6.7±0.6 | −100.5±0.6†| 7.9±0.5 |
Nav1.5 C981A 2BP | −43.2±0.7 | 8.5±0.6 | −104.8±0.9 | 10.3±0.8 |
Nav1.5 cardiomyocytes | −37.3±0.3 | 7.1±0.3 | −76.6±0.5 | 8.2±0.4 |
Nav1.5 cardiomyocytes 2BP | −42.2±0.6 | 8.5±0.5* | −99.4±0.6* | 10.1±0.5* |
Nav1.5 cardiomyocytes Palmitic acid | −36.1±0.5 | 6.7±0.5 | −71.0±0.5* | 7.3±0.5 |