Figure 2: Regional plots of association results and recombination rates for the newly identified risk loci for multiple myeloma.
From: Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Results for 6p22.3 (rs34229995), 6q21 (rs9372120), 7q36.1 (rs7781265), 8q24.21 (rs1948915), 9p21.3 (rs2811710), 10p12.1 (rs2790457), 16q23.1 (rs7193541) and 20q13.13 (rs6066835). Plots (using visPig70) show association results of both genotyped (triangles) and imputed (circles) SNPs in the GWAS samples and recombination rates. −Log10 P-values (y axes) of the SNPs are shown according to their chromosomal positions (x axes). The sentinel SNP in each combined analysis is shown as a large circle or triangle and is labelled by its rsID. The colour intensity of each symbol reflects the extent of LD with the top SNP, white (r2=0) through to dark red (r2=1.0). Genetic recombination rates, estimated using 1,000 Genomes Project samples, are shown with a light blue line. Physical positions are based on NCBI build 37 of the human genome. Also shown are the relative positions of genes and transcripts mapping to the region of association. Genes have been redrawn to show their relative positions; therefore, maps are not to physical scale. On the bottom is the chromatin-state segmentation track (ChromHMM) for lymphoblastoid cells using data from the HapMap ENCODE Project.
