Table 1 Somatic nonsilent mutations and copy-number variant genes in syCRCs.

From: Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Patient ID

Gender

Age at diagnosis (y/o)

Cancer type

Germline mutation

Tumour

Nonsilent mutations ( n)

CNV genes ( n)

S13

F

37

Lynch syndrome

MLH1: p.R100*

T1

523

6,059

     

T2

654

1,094

S6

M

40

Lynch syndrome

MSH2: p.Q718*

T1

1,150

3,546

     

T2

478

2

S3

F

29

FAP

APC: p. I1307K

T1

47

12,458

     

T2

52

9,222

S12

M

80

Sporadic

—

T1

72

14,109

     

T2

61

14,448

UH1

M

66

PJS

STK1: p.F354L

T1

1,232

7,448

     

T2

34

12,647

UH2

F

66

Sporadic

—

T1

822

2,429

     

T2

281

2

UH5

F

70

Sporadic

—

T1

569

8,788

     

T2

89

11,461

UH6

M

86

FCCTX

SEMA4A: p.P682S

T1

26

126

     

T2

75

1,013

UH8

M

69

Sporadic

—

T1

59

5,412

     

T2

37

11,029

UH11

M

65

Lynch syndrome

MLH1: p.G67R

T1

515

0

     

T2

1,021

658

  1. FAP, familial adenomatous polyposis; FCCTX, familial CRC type X; PJS, Peutz–Jeghers syndrome.
  2. Reported for each patient are the number of somatic nonsilent mutations (SNVs and InDels) and copy number variant (CNV) genes. Germline predisposing mutations are described according to the Human Genome Variation Society (http://www.hgvs.org/mutnomen).
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