Figure 3: Experimental support for reference cancer gene lists.
From: Challenges in identifying cancer genes by analysis of exome sequencing data
(a–c) Support for CGC cancer genes detected by any of the MAIN-METHODS for analysing tumour genomes (Cancer Detected) versus those cancer genes that were undetected by any of these (cancer undetected). Also shown is support for the AGO-NEG negative control set of non-cancer genes (Likely non-cancer) and the remainder of genes in the genome-wide background (all other genes). Whisker plots indicate mean and the 95% confidence interval of the mean. Support is evaluated using: (a) RNA-seq tumour-normal differential expression in The Cancer Genome Atlas (TCGA). (b) Number of times a gene has been identified in independent cancer genetic screens in mice. (c) Number of Project Achilles cell lines with a measured impact (top/bottom 10%) on growth as a result of shRNA knockdown. An asterisk (*) indicates a significant difference in medians was found between the two sets. (d) The number of cancer publications by year comparing detected and undetected CGC cancer genes.
