Figure 2: Determination of the Tower domain of FANCD2. | Nature Communications

Figure 2: Determination of the Tower domain of FANCD2.

From: The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2

Figure 2

(a) Schematic of FANCI and FANCD2 indicating the Tower domain. (b) Coomassie blue stain of recombinant full-length FANCD2–FANCI and FANCD2ΔTower–FANCI heterodimer purified from Sf9 cells. (c) Different orientations of Cryo-EM density map of the FANCD2ΔTower–FANCI complex. Scale bar, 20 Å. (d) Different orientations of Cryo-EM density map of full-length FANCD2–FANCI complex (in blue mesh) superimposed with the FANCD2ΔTower–FANCI complex (in gold). Scale bar, 20 Å.

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