Figure 6: Effect of B02 on telomeric DSBR.
From: Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
(a) Cells were treated and analysed as in Fig. 4a, with the addition of B02 (13.7 μM) as indicated. (b) Quantification of a, values are the average ±s.d. of three independent experiments. The signal intensity was quantified and normalized as described for Fig. 1c. **P<0.01. The Student’s t-test was used to determine the statistical significance. (c) Cells were treated as in a. DNA was isolated and analysed using the in-gel hybridization assay. After electrophoresis, telomeric C-probe or G-probe was hybridized under native or denaturing conditions. (d) Schematic diagrams show hypothesized repair of DSBs in telomeres.
