Figure 5: Transcriptome profiling reveals enrichment of the cell survival and apoptotic pathway genes in Tsc1cKO mutants. | Nature Communications

Figure 5: Transcriptome profiling reveals enrichment of the cell survival and apoptotic pathway genes in Tsc1cKO mutants.

From: Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

Figure 5

(a) Heatmap depicts gene expression of representative myelination-associated and apoptosis-related genes in control and Tsc1cKO optic nerves at P12. (b,c) Gene ontology analyses of pathway enrichment among (b) downregulated and (c) upregulated genes in Tsc1cKO as compared with control. (d–f) qRT–PCR analysis of representative (d) myelination-related genes and differentiation inhibitors, (e) lipid synthesis genes, and (f) apoptosis and stress response genes from optic nerves of control and Tsc1cKO mice at P12. Data represent the mean±s.e.m. from three animals. * P<0.05; ** P<0.01; *** P<0.001; Student’s t-test.

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