Figure 7: hLRRK2G2019S inhibits retrograde signalling.
From: LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
(a) Representative traces of mEJCs and EJC from larvae co-expressing dLRRK with hLRRK2wt (UAS-dLRRK/+; MHC-GAL4/UAS-hLRRK2wt) and larvae co-expressing dLRRK with hLRRK2G2019S (UAS-dLRRK/+; MHC-GAL4/UAS-hLRRK2G2019S). (b) Quantification of mEJC, EJC and QC from genotypes in a as well as control (MHC-Gal4/+). n=20, 20 and 22. (c) Representative traces of mEJCs and EJC from GluRIIA mutant larvae (Df(2L)cl-h4/GluRIIASP16) or GluRIIA mutant larvae expressing either wild-type or mutant hLRRK2 in muscle (Df(2L)cl-h4/GluRIIASP16; 24B-Gal4/UAS-hLRRK2wt and Df(2L)cl-h4/GluRIIASP16; 24B-Gal4/UAS-hLRRK2G2019S). (d) Quantification of mEJC, EJC and QC from c. n=20, 20 and 22. Error bars represent s.e.m. **P<0.01 and ***P<0.001.
