Figure 6: Anti-VEGF is predicted to synergize with anti-metabolic therapy.
From: Glycolytic regulation of cell rearrangement in angiogenesis
(a–d) Number of overtakes (a), the average (b) and maximal time (c) during which a salt and pepper (S&P) pattern is maintained, and the time required to acquire a stable S&P pattern (d) for in silico WT (isWT) ECs in non-mosaic sprouts, in which PFKFB3 was pharmacologically blocked (isPFKFB3PI) simulated by modifying EFIL/ADH and blocking VEGF signalling (green; ‘isPFKFB3PI-FIL/ADH sprout and SU5416’) in VEGF levels 10-fold higher than normal (10 × nVEGF). The white and black bars represent a simulated isWT sprout in normal VEGF (nVEGF) and 10 × nVEGF levels, respectively. The horizontal red and blue dotted lines show the particular values of an isWT sprout in normal and 10x VEGF levels, respectively. ts, timestep. Data are mean±s.e.m.; n=50; NS, not significant, ***P<0.001 versus isWT in nVEGF; the statistical significance between the black and green bars is also indicated (**P<0.01, ***P<0.001); Student’s t-test.
