Figure 8: Ensemble sodium channel activity is accurately reported in cell-attached patches.
From: Errors in the measurement of voltage-activated ion channels in cell-attached patch-clamp recordings
(a) Trains of ensemble sodium channel activity (IC-A) recorded in a cell-attached patch under simultaneous whole-cell current- and voltage-clamp conditions from the soma of thalamocortical neuron. The small intracellular voltage deviations recorded under whole-cell current-clamp (Vm) are shown. (b) Pooled data showing the similarity in the peak amplitude of ensemble sodium channel activity recorded in cell-attached patches under simultaneous voltage- (v-c) or current-clamp (c-c) conditions. Pooled data (n=7) represent mean±s.e.m. (c) Linear relationship between the peak amplitude of ensemble sodium channel activity in cell-attached patches and intracellular depolarization for the first current of each train. Data have been fit by linear regression (line).
