Figure 2: Tuning similarity depends on cortical distance in mouse V1.
From: Spatial clustering of tuning in mouse primary visual cortex
(a) Sample of estimates of the joint tuning of neurons in the orientation and spatial frequency plane in four cells. The origin is in the middle of the image. Kernels are individually normalized, so the maximum absolute value is one. (b) Average tuning similarity decreases as a function of cortical distance. Error bars represent ±1 s.e.m. The size of the data points denotes the significance of a rank-sum test comparing the median distribution of data at a given distance to the distribution of the rightmost bin near 200 μm. Red, dashed line shows the best exponential fit to the data. Inset: the mean tuning profile in mouse V1. The number of cell pairs in each group, in order of increasing cortical distance, are n=894, 2,538, 3,473, 3,845, 3,792, 3,399 and 2,964. (c) Demonstration of clustering within a single imaging field. Top, segmented cells. Middle, estimated kernels. Bottom, scatter plot of tuning similarity versus cortical distance. There is a statistically significant negative correlation between receptive field similarity and cortical distance. (d) Distributions of the absolute difference in preferred orientation as a function of cortical distance for cells within 50 μm of each other (left panel) and at least 150 μm away from each other (right panel) for the data in (b).
