Figure 1: Development of genetically encoded photocrosslinker with a transferable MS-label.

(a) In situ generation of MS-label on prey proteins by using a genetically encoded cleavable photocrosslinker. (b) Chemical design of the photocrosslinker (DiZHSeC) with transferable MS-label. The in situ generated NPAA MS-label can be verified by either fluorogenic labelling or can be directly identified by mass spectrometry.