Figure 7: TLR2 protects mice against sepsis caused by PSM-producing S. aureus.
From: Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
TLR2 has only a minor impact on survival of mice infected with Agr or PSM-deficient S. aureus USA300 (a,b) but protects mice infected with USA300 wild-type (c). The FPR2 receptor has no major impact on the course of systemic S. aureus infection. Mice were infected with 1 × 107 CFU of USA300 wild-type (18 non-transgenic, 8 TLR2−/−, 10 FPR2−/− C57BL/6 animals), with USA300 Δα,β,hld (8 non-transgenic, 8 TLR2−/−, 10 FPR2−/− C57BL/6 animals), or USA300 Δagr (10 non-transgenic, 12 TLR2−/− C57BL/6 animals). Survival curves were monitored for statistical significance versus wild-type mice by the log-rank test.
