Figure 4: Angptl4−/− BM recipients have more apoptosis in the atherosclerotic lesions. | Nature Communications

Figure 4: Angptl4−/− BM recipients have more apoptosis in the atherosclerotic lesions.

From: ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Figure 4

(a-d) Representative histological analyses of the cross-sections of the aortic sinus from Ldlr−/− chimeras with WT or Angptl4−/− BM after 12 weeks on WD stained with (a) H&E showing necrotic areas within dotted boundary (scale bars, 400 μm), (b) TUNEL; inset shows magnified TUNEL-positive area (scale bars, 200 μm), (c) CD68/α-SMA/DAPI (scale bars, 200 μm), (d) CD68/Ki67/DAPI (scale bars, 200 μm) and (e) Picrosirius Red staining (scale bars, 200 μm). Total necrotic area, TUNEL-positive nuclei, macrophage content, Ki67-positive macrophages and collagen content are quantified in the right panels. N=10 per group for a–d and n=6 per group for e. All data are the mean±s.e.m.; *P<0.05 by comparison with data from Ldlr−/− chimeras with WT BM by unpaired t-test.

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