Figure 5: Haematopoietic ANGPTL4 deficiency causes vascular inflammation and leukocytosis. | Nature Communications

Figure 5: Haematopoietic ANGPTL4 deficiency causes vascular inflammation and leukocytosis.

From: ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Figure 5

(a) mRNA expression of inflammatory genes in the whole aorta of Ldlr−/− chimeras with WT or Angptl4−/− BM after 12 weeks on WD (n=9 per group). (b) Dot plots showing gating schemes of macrophages and monocytes from whole aorta of Ldlr−/− chimeras with WT or Angptl4−/− BM after 12 weeks on WD. (right) The quantification of total number of macrophages and Ly-6Chigh monocytes (n=6 per group). (c) Representative flow cytometry plots showing monocyte and neutrophil populations from Ldlr−/− chimeras with WT or Angptl4−/− BM after 12 weeks on WD. Total monocytes and neutrophils are quantified on the right panel by extrapolating the proportion of cells from flow cytometry to the total number of leukocytes per μl measured using Hemavet haematology analyser (n=10 per group). All data are the mean±s.e.m.; *P<0.05 by comparison with data from Ldlr−/− chimeras with WT BM by unpaired t-test.

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