Figure 8: ANGPTL4 deficiency results in monocytosis and massive atherosclerosis. | Nature Communications

Figure 8: ANGPTL4 deficiency results in monocytosis and massive atherosclerosis.

From: ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Figure 8

Schematic diagram showing haematopoietic ANGPTL4 function in atherosclerosis. ANGPTL4 is induced in macrophages in response to lipoprotein loading. ANGPTL4 deficiency in macrophages results in increase in foam cell formation, inflammation and apoptosis of macrophages within atherosclerotic plaques. Concomitantly, ANGPTL4 deficiency in haematopoietic cells results in an increase in the frequency and survival of CMPs, and upon WD feeding results in an elevated level of circulating monocytes. Overall, ANGPTL4 deficiency in haematopoietic cells promotes massive atherosclerosis.

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