Figure 1: Phenotypic alterations in clinical ALL samples following CD19 CAR. | Nature Communications

Figure 1: Phenotypic alterations in clinical ALL samples following CD19 CAR.

From: CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

Figure 1

(a,c,e,g) Fever curves, CRP values and clinical response to CD19 CAR treatment. (b,d,f,h) Bar graph demonstrating percent of cells expressing cell surface markers by flow cytometry in the bone marrow, gated on leukaemic blasts, with representative flow cytometry histograms of CD19 and CD11b on the right (grey, control; blue, pre-CAR; red, post CAR). (a,b) Pre-CAR sample and day +30 post-CAR sample from a patient who did not experience CRS following CD19 CAR. (c,d) Pre-CAR and +180 days post-CAR samples from a patient with normal karyotype multiple relapsed ALL, who had a severe CRS followed by an MRD-negative complete response with CD19 CAR, with no CAR+ cells persisting beyond 60 days. (e,f) Pre-CAR and day +30 post-CAR samples from a patient with normal karyotype ALL who experienced a mild CRS and CAR expansion, but had persistent disease. (g,h) Pre-CAR and post-CAR samples from an infant with MLL-rearranged ALL, treated with CD19-41BB-zeta CAR, who relapsed with myeloid blasts.

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