Figure 7: Digitoxin and MEK inhibitor inhibit tumour growth partly by inhibiting NHE function.
From: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
(a) Graphical summary of the mechanism by which digitoxin plus MEK inhibitor inhibit melanoma growth. (b,c) NSG mice with subcutaneous xenografts (M481 and M214) expressing vector (tRFP control) or NHE1 were treated daily with digitoxin and/or MEK inhibitor to examine the effect on tumour diameter (n=4–5 mice per treatment per melanoma; each melanoma tested in an independent experiment). All data represent mean±s.d. Statistical significance was assessed by two-way analysis of variance followed by Dunnett’s multiple comparisons test (NS, not significant; *P<0.05; **P<0.01; ***P<0.001).
