Figure 3: Mode of action of serine-β-lactamases and binding mode of cyclic boronates. | Nature Communications

Figure 3: Mode of action of serine-β-lactamases and binding mode of cyclic boronates.

From: Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Figure 3

(a) Outline mode of action of SBLs. (b) View from a structure obtained by co-crystallization of 1 with OXA-10 (Chain A) revealing the binding mode of cyclic boronates to SBLs. (c) The overlay compares the binding modes of 1 and hydrolysed benzylpenicillin in complex with OXA-10 (PDB ID: 2WGI).

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