Table 2 In vitro cell-based screening of cyclic boronate 2.
Bacterial strain | Genotype (β-lactamases) | 2 MIC (μg ml−1) | Meropenem MIC (μg ml−1) | Meropenem MIC (μg ml − 1 ) (10 μg ml −1 2) | Meropenem MIC (μg ml − 1 ) (25 μg ml −1 2) |
|---|---|---|---|---|---|
K. pneumoniae Ecl8 pSU18 | bla SHV-1 | >128 | ≤0.25 | ≤0.25 | ≤0.25 |
K pneumoniae Ecl8 ΔramR pSU18 | bla SHV-1 | >128 | ≤0.25 | ≤0.25 | ≤0.25 |
K. pneumoniae Ecl8 pSU18:NDM-1 | blaSHV-1; blaNDM- 1 | >128 | >128 | 8 | 4 |
K pneumoniae Ecl8 ΔramR pSU18:NDM-1 | blaSHV-1; blaNDM- 1 | >128 | >128 | 16 | 2 |
E. coli IR10 | blaDHA-1; blaCTX-M-15; blaTEM-1; blaOXA-1; blaNDM- 1 | >128 | 128 | 8 | 2 |
E. coli IR60 | blaDHA-1; blaCTX-M-15; blaTEM-1; blaOXA-1; blaNDM- 1 | >128 | 64 | 16 | 16 |
K. pneumoniae IR8 | blaSHV-1; blaDHA-1; blaCTX-M-15; blaTEM-1; blaNDM-1 | >128 | 128 | 32 | 16 |
