Figure 7: Brca2cko/cko mice with K14-Cre are tumour prone in a Parp1ko/+ background. | Nature Communications

Figure 7: Brca2cko/cko mice with K14-Cre are tumour prone in a Parp1ko/+ background.

From: Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

Figure 7

(a) Kaplan–Meier curves showing tumour-free survival percentage of K14-Cre; Brca2cko/cko mice under Parp1+/+ or Parp1ko/+ genetic background. (b) Model to explain the targeting of BRCA2-deficient tumours by PARPi and the potential concern related to its role in cell survival.

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