Figure 3: miR-625-3p regulates networks associated with therapy response. | Nature Communications

Figure 3: miR-625-3p regulates networks associated with therapy response.

From: miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells

Figure 3

(a) Unsupervised clustering of the most variable probe sets across three SW620.625 and three SW620.ctrl samples after DOX induction. (b) Expression profiles of primary tumours from first-line oxPt-treated mCRC patients were generated and 20,693 genes ranked according to difference in median expression between non-responder (n=9) and responder (n=17) patients. Genes upregulated in the SW620.625 cells (black vertical bars) were significantly associated with the non-responder phenotype (enrichment score=0.367, P=0.036, Kolmogorov–Smirnov test).

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