Figure 5: TA SHH-positive cells do not allow cSCC development. | Nature Communications

Figure 5: TA SHH-positive cells do not allow cSCC development.

From: Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Figure 5

(a) PO4-SMAD3 IHC in anagen human (left panel) and mouse (right panel) hair follicles reveals immunoreactivity in the hair matrix. CTL, connective tissue layer; DP, dermal papilla; IRS, inner root sheath; ORS, outer root sheath. Scale bar, 100 μm (b) Kaplan–Meier survival curve of ShhCreER BrafV600E (n=13), ShhCreER BrafV600E Tgfbr1fl/+ (n=28) and ShhCreER BrafV600E Tgfbr1fl/fl (n=39) mice. (c) Kaplan–Meier survival curve of ShhCreER KrasG12D (n=17) and ShhCreER KrasG12D Tgfbr1fl/fl (n=21) mice.

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