Figure 8: Deletion of Tgfbr1 coupled with Tp53 mutation/deletion leads to skin tumorigenesis. | Nature Communications

Figure 8: Deletion of Tgfbr1 coupled with Tp53 mutation/deletion leads to skin tumorigenesis.

From: Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Figure 8

(a) Kaplan–Meier survival curve of Lgr5CreER Tp53R172H/fl (n=31), Lgr5CreER Tp53R172/+ Tgfbr1fl/fl (n=10), Lgr5CreER Tp53fl/+ Tgfbr1fl/fl (n=5) and Lgr5CreER Tp53R172H/fl Tgfbr1fl/fl (n=11) mice (P≤0.0001 by log-rank, Mantel–Cox). (b) Tumour number of indicated genotypes. (c) Macroscopic picture of a Lgr5CreER Tp53R172H/fl Tgfbr1fl/fl mouse with a skin tumour. Representative staining of haematoxylin and eosin, Keratin 1 (K1) and Keratin 5 (K5) is shown. Scale bar, 100 μm.

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