Table 1 Interaction of 28 genome-wide significant BCC associations in stage 1 with melanoma.
From: Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma
SNP | Gene | N effect | N SE | N P | Y effect | Y SE | Y P | IntP |
|---|---|---|---|---|---|---|---|---|
rs12203592 | IRF4 | 0.397 | 0.017 | 5.4 × 10−117 | 0.454 | 0.060 | 4.5 × 10−14 | 0.040 |
rs1805007 | MC1R | 0.321 | 0.023 | 8.8 × 10−41 | 0.272 | 0.077 | 4.7 × 10−4 | 0.286 |
rs214785 | TGM3 | −0.197 | 0.017 | 1.7 × 10−29 | −0.044 | 0.065 | 5.0 × 10−1 | 0.213 |
rs35407 | SLC45A2 | 0.483 | 0.053 | 1.1 × 10−22 | 0.537 | 0.239 | 2.0 × 10−2 | 0.751 |
rs6059655 | RALY | −0.219 | 0.024 | 5.7 × 10−19 | −0.141 | 0.082 | 8.5 × 10−2 | 0.088 |
rs57142672 | RCC2 | 0.128 | 0.014 | 1.2 × 10−18 | 0.214 | 0.052 | 4.4 × 10−5 | 0.612 |
rs73635312 | GATA3 | 0.189 | 0.021 | 3.5 × 10−20 | 0.109 | 0.074 | 1.4 × 10−1 | 0.047 |
rs1126809 | TYR | −0.126 | 0.015 | 2.3 × 10−16 | −0.070 | 0.053 | 1.8 × 10−1 | 0.521 |
rs421284 | CLPTM1L | 0.138 | 0.014 | 1.1 × 10−22 | 0.046 | 0.050 | 3.5 × 10−1 | 0.783 |
rs2080303 | ALS2CR12/CASP8 | 0.122 | 0.016 | 1.1 × 10−14 | 0.068 | 0.057 | 2.3 × 10−1 | 0.425 |
rs61824911 | RHOU | 0.139 | 0.016 | 9.3 × 10−18 | −0.023 | 0.061 | 7.1 × 10−1 | 0.300 |
rs2116709 | FOXP1/EIF4E3 | −0.116 | 0.015 | 1.3 × 10−14 | −0.061 | 0.054 | 2.6 × 10−1 | 0.136 |
rs12916300 | OCA2/HERC2 | 0.142 | 0.019 | 9.7 × 10−15 | −0.024 | 0.067 | 7.2 × 10−1 | 0.761 |
rs141115006 | RGS22 | −0.143 | 0.020 | 3.1 × 10−13 | −0.077 | 0.071 | 2.8 × 10−1 | 0.819 |
rs10810657 | BNC2 | −0.108 | 0.014 | 7.2 × 10−14 | −0.078 | 0.052 | 1.4 × 10−1 | 0.986 |
rs10093547 | ZFHX4 | 0.219 | 0.031 | 5.1 × 10−13 | 0.147 | 0.106 | 1.6 × 10−1 | 0.755 |
rs191177147 | LPP | 0.114 | 0.016 | 6.3 × 10−13 | 0.009 | 0.057 | 8.8 × 10−1 | 0.517 |
rs9275642 | HLA-DQB1/DQA2 | −0.123 | 0.019 | 2.4 × 10−11 | −0.080 | 0.065 | 2.2 × 10−1 | 0.346 |
rs7874604 | CDKN2B | 0.098 | 0.015 | 1.6 × 10−10 | 0.095 | 0.055 | 8.5 × 10−2 | 0.591 |
rs11170164 | KRT5 | 0.163 | 0.025 | 1.2 × 10−10 | 0.134 | 0.094 | 1.6 × 10−1 | 0.303 |
rs73183643 | CUX1 | 0.109 | 0.017 | 1.1 × 10−10 | 0.067 | 0.060 | 2.6 × 10−1 | 0.391 |
rs11993814 | ZBTB10 | −0.097 | 0.016 | 2.1 × 10−9 | −0.146 | 0.058 | 1.2 × 10−2 | 0.413 |
rs2776353 | LINC00111 | −0.092 | 0.015 | 1.5 × 10−9 | −0.063 | 0.055 | 2.5 × 10−1 | 0.623 |
rs1765871 | ATP11A | −0.068 | 0.014 | 1.1 × 10−6 | −0.145 | 0.052 | 4.8 × 10−3 | 0.981 |
rs10425559 | TICAM1/PLIN3 | 0.086 | 0.014 | 2.7 × 10−9 | 0.004 | 0.052 | 9.3 × 10−1 | 0.458 |
rs1050529 | HLA-B | −0.106 | 0.019 | 2.5 × 10−8 | −0.096 | 0.069 | 1.7 × 10−1 | 0.486 |
rs7776701 | TNS3 | −0.081 | 0.014 | 6.9 × 10−9 | 0.041 | 0.050 | 4.1 × 10−1 | 0.711 |
rs78097823 | TTC28 | 0.164 | 0.034 | 2.4 × 10−6 | 0.354 | 0.120 | 3.5 × 10−3 | 0.466 |
