Figure 6: Cross-talk between genome and epigenome.
From: reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4+ memory T cells
(a–c) The filled circles denote the relative fraction of TSSs in the indicated state. Purple indicates H3K4me3-only, red H3K27me3-only, black bivalent and grey the unmodified state. Continuous lines indicate possible transitions, while broken lines indicate a low probability of a transition between the states. (d,e) Possible models promoting either a bivalent (d) or H3K4me3-only state (e) as depicted in a. H3K4me3X and H3K27me3Y indicate that they reside on two different H3-tails, while H3K4me3XY indicates that H3K4me3 is on both H3-tails of a nucleosome.
