Figure 1: Snapshots of Foldit players building YPL067C in the Foldit user interface.
From: Determining crystal structures through crowdsourcing and coursework
For the complete path of the Foldit model building, see Supplementary Movie 1. The starting point for the puzzle (top left) presented the electron density map and the protein sequence to the player. The players then used Trp108 to help anchor the sequence in electron density (top middle) before beginning to fold secondary structure elements (top right through bottom left). After many rounds of modification in Foldit (bottom middle and Supplementary Movie 1), the players arrived at a high-scoring solution in which the ordered regions of electron density were well fit by YPL067C (bottom right). Disordered regions were later pruned.
