Figure 2: Activation of Hedgehog signalling in GPCs, but not MCPCs, before gonadogenesis. | Nature Communications

Figure 2: Activation of Hedgehog signalling in GPCs, but not MCPCs, before gonadogenesis.

From: Hedgehog–BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos

Figure 2

(a–f) mRNA expression of SHH (a–c) and its target gene PATCHED (d–f) are shown in chicken embryos at E1.7 (a,d), E2.0 (b,e) and E2.3 (c,f). SHH is expressed in the endoderm (black arrowheads) in addition to floor plate (open arrowheads) and notochord (asterisks). (g–i) Localizations of SHH and PATCHED mRNAs are illustrated with dark and light purple, respectively. PATCHED expression was detected in the future gonadal area (outlined in red) composed of coelomic epithelium (black arrows) and coelomic epithelial cell-derived underlying mesenchyme adjacent to the endoderm. PATCHED expression was not detected in MCPCs, which are more distant from the endoderm (white arrows). Scale bars, 50 μm.

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