Figure 7: Cep295 ensures daughter-to-mother centriole conversion via Cep192 recruitment onto the newly formed daughter centriole wall.
From: Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole
A speculative model of the role of Cep295 in centriole biogenesis. Cep295 promotes recruitment of Cep192 onto the wall of a newly formed daughter centriole. Cep295 is also critical for the integrity of the proximal part of the daughter centriole and for stability of the resulting centriole in the next cell cycle. The events coordinated by Cep295 are thus critical for the ability of a new mother centriole to duplicate, recruit PCM components and act as the MTOC.
