Figure 4: X-ray crystallographic analysis of KasA complexed with GSK3011724A.
From: Identification of KasA as the cellular target of an anti-tubercular scaffold
(a) Co-crystal structure of KasA dimer (yellow, blue) with GSK3011724A (green space filled) and PEG (green sticks) bound with the open conformation of the acyl channel. The active site cysteine C171 is shown in line format, as are an overlay of the TLM and a phospholipid ligand taken from PDB entry 4C72 (ref. 25). (b) GSK3011724A and PEG both shown in stick format filling the acyl channel. (c) Hydrogen bonds between GSK3011724A and E199 within the binding site.
