Figure 1: PP1 inhibition and NOR training induce differential expression of several miRNAs in the mouse hippocampus. | Nature Communications

Figure 1: PP1 inhibition and NOR training induce differential expression of several miRNAs in the mouse hippocampus.

From: The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner

Figure 1

NIPP1* and control mice were trained on an NOR task (trained) or exposed to the training chamber alone (non-trained). Deep sequencing was conducted on pooled hippocampal samples (n=6 in each group) collected 30 min after the end of training. Several miRNAs are differentially expressed (adjusted P<0.05) in non-trained NIPP1* mice compared with non-trained controls (a, expressed as log 2 of fold change), and in trained controls compared with non-trained controls (b, expressed as log 2 of fold change). Some of the miRNAs identified by deep sequencing were similarly upregulated in an independent set of experiments in both non-trained NIPP1* mice (c, miR-183: controls, n=11; NIPP1*, n=11; t20=2.19, *P<0.05; miR-182: controls, n=11; NIPP1*, n=11; t20=2.68, *P<0.05); and control mice trained on NOR (d; miR-183: non-trained, n=12; trained, n=13; t23=2.07, *P⩽0.05; miR-182: non-trained, n=13; trained, n=13; t24=2.32, *P<0.05). Bar graphs represent mean±s.e.m.

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