Figure 3: Analyses of pri-miRNA processing. | Nature Communications

Figure 3: Analyses of pri-miRNA processing.

From: The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner

Figure 3

(a) Relative signal of firefly luciferase (FL) to renilla luciferase (RL) is reduced in pmirGLO_pri-miR-182 transfected cells (Pri-miR-182) compared with control cells transfected with an empty vector (Control) (t4=9.8, ***P<0.001). (b–d) Overexpression of a nuclear inhibitor of PP1 (NIPP1 OE) reduces FL/RL signal in cells expressing pri-miR-183 (b, t5=2.71, *P<0.05) and pri-miR-182 (c, t4=7.45, **P<0.01), but not pri-miR-10b (d, t4=1.83, P=0.14), fused to a luciferase reporter. Bar graphs represent mean±s.e.m.

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