Figure 1: Anatomic distribution and histology of representative tissues isolated from human patients and Hairless mice. | Nature Communications

Figure 1: Anatomic distribution and histology of representative tissues isolated from human patients and Hairless mice.

From: Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Figure 1

(a–c) Normal (peri-tumoural) skin, actinic keratosis and invasive cuSCC, respectively, are shown from human patients. Scale bar, 50 μm. Human samples were processed following combined RNAlater and formalin fixation, resulting in significant cytoplasmic shrinkage. (d–f) Normal (peri-tumoural) skin, papillomas and invasive cuSCC, respectively, are shown from Hairless mice. (g) Anatomic locations of matched samples from human patients. (h) Tabular list of matched samples from human patients: (S) denotes the cuSCC with adjacent NS, (N) denotes normal skin and (A) denotes the AK. For patient 1, only NS and AK were available for analysis. (i) Representative skin samples from Hairless mice are shown, which include smaller papillomas and a smaller number of invasive carcinomas.

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