Figure 6: microRNA profiling across AK/papilloma and cuSCC development. | Nature Communications

Figure 6: microRNA profiling across AK/papilloma and cuSCC development.

From: Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Figure 6

(a) Correlation matrix of microRNAs differentially expressed in at least one signature in human samples shows that significantly improved discrimination between three sample types is achieved as compared with mRNA profiles. (b) Using only microRNAs differentially expressed in at least two out of three pairwise comparisons (P<0.05), robust discrimination is achieved between NS and cuSCC with most AKs occupying an intermediate expression pattern. (c) Hierarchical clustering of microRNAs differentially expressed in at least one signature in mouse samples shows distinct patterns among the three sample types as compared with mRNA profiles. (d) Using only microRNAs differentially expressed in at least two of three pairwise comparisons (P<0.05), CHR and cuSCC are very strongly segregated with an intermediate group dominated by PAP.

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