Figure 7: Functional pair analysis identifies highly interconnected microRNA/mRNA regulatory networks conserved across species. | Nature Communications

Figure 7: Functional pair analysis identifies highly interconnected microRNA/mRNA regulatory networks conserved across species.

From: Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Figure 7

This occurs for both (a) upregulated microRNAs/downregulated target mRNAs and for (b) downregulated microRNAs/upregulated target mRNAs. The figures only show those microRNAs with q<10−8, log2-fold change of >1.15, conserved between species. Validation of select microRNA/mRNA pairs using a distinct set of human matched samples demonstrate robustness of the findings. (c) miR-21 is upregulated between NS and cuSCC, whereas predicted targets ARHGAP24 and TIMP3 are downregulated. (d) miR-31 is upregulated between NS and cuSCC, whereas predicted targets PTPN14 and FAM134B are downregulated.

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