Table 2 Site-specific mutational overlap.

From: Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

PT

NS Total

AK Total

SCC Total

NS/AK

AK/SCC

NS/SCC

NS/AK/SCC

SCC1 versus SCC2

NS/AK/SCC1

NS/AK/SCC2

NS/AK/SCC1/SCC2

1

1,264

449

—

2

—

—

—

—

—

—

—

2

—

1,631

1,332

—

4

—

—

—

—

—

—

3

—

1,555

9,156

—

6

—

—

—

—

—

—

4

257

1,056

385

0

1

0

—

—

1

—

1

4 (SCC2)

—

—

578

—

0

1

—

195

—

0

1

5

24

1,447

4,924

1

6

0

1

—

—

—

—

6

347

—

3,614

—

—

6

—

—

—

—

—

8

319

—

503

—

—

2

—

—

—

—

—

10

23

1,873

—

0

—

—

—

—

—

—

—

12

—

290

—

—

—

—

—

—

—

—

—

Average

   

0.75

3.4

1.8

     
  1. AK, actinic keratosis; cuSCC, cutaneous squamous cell carcinoma; NS, normal skin.
  2. The overlap of site-specific variants in NS, AK and cuSCC shows that the greatest amount of overlap between AK and cuSCC. These average 3.4 between AK and cuSCC, 0.75 between NS and AK, and 1.8 between NS and cuSCC. The most overlap occurred between two SCCs from patient 4 (195), which were from two distinct lesions in close physical proximity, suggesting that they may have arisen at least partially from a common clone.
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