Figure 2: Balanced inversions in radiation-associated tumours.
From: Mutational signatures of ionizing radiation in second malignancies
(a) Overview of rearrangements. Tumours exhibited tumour-type specific features. Balanced inversions (black bars) were found in every tumour, except PD7530a. (b) Example of a balanced inversion in PD7188a. A 0.9 Mb inversion. The inversion was validated by PCR across the breakpoint (gel image) and by split reads. Note that the split reads carried a heterozygous SNP at the head end.
