Figure 3: Indels in prostate tumours.

(a) Indels in radiation-naive versus radiation-exposed prostate tumours. Shown is the indel burden, by indel subtype, found in radiation-naive and in radiation-exposed prostate tumours. In radiation-exposed tumours radiotherapy had been administered to the primary tumour before formation of metastases. Deletions were significantly enriched in radiation-exposed tumours (P=0.0002, generalized linear model). Note that radiation-associated tumours with confounding BRCA1 or BRCA2 deficiency were excluded from the statistical analysis (cases PD13412 and PD11335). (b) Indels in tumours from a patient whose primary lesion was treated with ionizing radiation after formation of metastases. Shown are indels that were found exclusively in the primary lesion and indels found in all other lesions. Deletions were significantly enriched amongst indels exclusive to the primary lesion. Comparison by Fisher’s exact test, of the ratio of deletions over other indels.