Figure 5: PPX and PPX_Δ12 reduce thrombus formation in blood under flow.
From: Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
Citrated whole blood from human and mice, readjusted to physiologic Ca2+ and Mg2+ concentrations, was perfused for 4 min over a collagen-coated surface at an arterial (a,c) or venous (b,d) shear rate. Representative phase-contrast images of thrombi formed during perfusion in the absence or presence of indicated PPX (a,b) or PPX_Δ12 (c,d) concentrations. Scale bars, 20 μm. Columns give the percentage of surface area covered by thrombi. Mean±s.e.m., from four independent experiments, ***P<0.001 by one-way analysis of variance.
