Figure 8: PPX and PPX_Δ12 do not interfere with haemostasis.
From: Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection
Wild-type mice were intravenously injected with buffer, PPX, PPX_Δ12 (150 mg kg−1 BW each) or heparin (200 U kg−1 BW). Bleeding times and blood loss from clipped tail injury assessed the haemostatic capacity of treated and F12−/− mice. (a) Bleeding time and (b) total haemoglobin loss determined by absorbance of haemoglobin in 37 °C PBS at λ=575 nm. (c) Tail-bleeding times were analysed by gently absorbing blood with a filter paper. Each symbol represents one animal; bars within each column indicate the mean, ***P<0.001, *P<0.05, NS=non-significant by one-way analysis of variance.
