Figure 1: Summary of the approach and transcriptional misregulation of CEN/KT genes across cancer types. | Nature Communications

Figure 1: Summary of the approach and transcriptional misregulation of CEN/KT genes across cancer types.

From: Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Figure 1

(a) Schematic overview of the centromere and kinetochore on replicated mitotic sister chromatids. CENP-A nucleosomes (purple) are the structural base for centromeric chromatin and kinetochore formation, and the CCAN network (blue) in the inner-kinetochore connects CENP-A chromatin to the KMN network (yellow) at the outer kinetochore. (b) The list of 31 CEN/KT genes. Cells are highlighted with colours matching (A) except for HJURP (purple) and Mis18 complex members (gray), which transiently localize to centromeres for new CENP-A assembly. The Affymetrix probes for CENP-P did not pass the specificity qualifier filter, and CENP-P was indicated with no value and subsequently removed from all other analysis. The graph to the right shows that 15 out of 31 CEN/KT genes are misexpressed (fold change ⩾2-fold, FDR-adjusted P<0.05) in >50% of data sets for nine cancer types, specifically breast, cervical, head and neck (including nasopharyngeal), colon, gastric, brain and CNS, liver, lung, and pancreatic cancers, compared with their corresponding normal tissues, or between late- and early-stage lesions. Also see Supplementary Data 1. (c) A flow chart showing the overall research strategy.

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