Table 3 Correlation between cancer cell line CES values and IC50s for irinotecan and topotecan in CCLE cancer cell lines.

From: Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

CCLE cell lines

Irinotecan

Topotecan

 

Spearman’s rho

P value

n

Spearman’s rho

P value

n

Breast

−0.644

0.007*

16

−0.247

0.281

21

Lung

−0.419

0.005*

44

−0.425

0.0001*

77

Ovary

−0.623

0.003*

20

−0.469

0.018*

25

Haematopoietic and lymphoid

−0.344

0.017*

48

−0.092

0.468

65

Skin

0.200

0.327

26

−0.163

0.364

33

CNS

−0.203

0.436

17

−0.126

0.568

23

Pancreas

−0.439

0.078

17

−0.143

0.536

21

Pooled

−0.384

<0.000001*

277

−0.339

<0.000001*

412

  1. CCLE, Cancer Cell Line Encyclopedia; CES, Centromere and kinetochore gene Expression Score; IC50, half maximal inhibitory concentration.
  2. Significant two-tailed P values for Spearman’s correlation coefficient rho are indicated by asterisks (P<0.05).
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