Figure 6: L7-Shank2−/− mice show impaired motor learning.
From: Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
(a,b) After 3 days of training, WT (n=9) but not L7-Shank2−/− mice (n=6) (P=0.018) learned to increase their speed during a conditioned ErasmusLadder test using tone-cued rung displacements. (c,d) In vestibulo-ocular reflex (VOR) gain increase training, L7-Shank2−/− mice (n=8) were not able to adapt their gain like WTs did (n=7) (P=0.006). (e,f) L7-Shank2−/− mutants (n=9) did not adapt their VOR phase following a reversal training paradigm, whereas WT (n=9) did (second day, P=0.047; third, P=0.0013; fourth, P<0.0001; fifth, P=0.0003). (g–i) Impaired percentage (P=0.0013) and amplitude (P=0.0009) of conditioned responses (CRs) in L7-Shank2−/− mice (n=10) compared with WT (n=11) in an eye-blink conditioning paradigm (200 paired trials daily). Data are represented as mean±s.e.m.. Single and double asterisks indicate P<0.05 and P<0.01, respectively. All tests were repeated-measures ANOVAs.
