Figure 7: In vivo simple spike firing characteristics in L7-Shank2−/− Purkinje cells.
From: Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
(a) Extracellular PC traces recorded from anterior lobules (I–V) in WT (top) and L7-Shank2−/− (bottom) mice. (b–d) Firing characteristics in the anterior lobules reveal a difference in CV2 (P=0.0092) between L7-Shank2−/− (n=25/3, cells per animals) and WT (n=23/3). (e) Example PC traces from posterior lobules (IX–X). (f–h) PCs from the posterior cerebellum in L7-Shank2−/− (n=21/3) showed significantly higher CV (P<0.0001) and CV2 (P<0.0001) values compared with WT (n=25/3). (i) Example PC traces from posteriorly located flocculus, which is responsible for VOR learning. (j–l) Again, L7-Shank2−/− (n=19/2) shows significantly higher CV (P<0.0001) and CV2 (P<0.0001) values than WT (n=23/2). Double asterisks denote P<0.01. All tests were two-sided t-tests.
